Neurobiology of Disease A Rapamycin-Sensitive Signaling Pathway Is Essential for the Full Expression of Persistent Pain States

نویسندگان

  • Sandrine M. Géranton
  • Lydia Jiménez-Díaz
  • Carole Torsney
  • Keri K. Tochiki
  • Sarah A. Stuart
  • J. Lianne Leith
  • Bridget M. Lumb
  • Stephen P. Hunt
چکیده

Sandrine M. Géranton,1* Lydia Jiménez-Díaz,1,4* Carole Torsney,2 Keri K. Tochiki,1 Sarah A. Stuart,1 J. Lianne Leith,3 Bridget M. Lumb,3 and Stephen P. Hunt1 1Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom, 2Centre for Integrative Physiology, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom, 3Department of Physiology, University of Bristol, Bristol BS8 1TD, United Kingdom, and 4Departamento Fisiología, Facultad Medicina, Instituto Neurociencias Castilla y León, Universidad de Salamanca, Salamanca 37007, Spain

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Eupafolin ameliorates lipopolysaccharide-induced cardiomyocyte autophagy via PI3K/AKT/mTOR signaling pathway

Objective(s): Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of eupafolin on LPS-induced cardiomyocyte autophagy...

متن کامل

A rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states.

Translational control through the mammalian target of rapamycin (mTOR) is critical for synaptic plasticity, cell growth, and axon guidance. Recently, it was also shown that mTOR signaling was essential for the maintenance of the sensitivity of subsets of adult sensory neurons. Here, we show that persistent pain states, but not acute pain behavior, are substantially alleviated by centrally admin...

متن کامل

Electroacupuncture attenuates chronic fibromyalgia pain through the phosphorylated phosphoinositide 3-kinase signaling pathway in the mouse brain

Objective(s): Fibromyalgia (FM) is a central nervous system disorder characterized by widespread mechanical hyperalgesia due to unknown mechanisms. Several inflammatory mediators, such as interleukin-1 (IL-1), IL-6, IL-8, and tumor necrosis factor, are increased in the serum of FM patients. Although medications including pregabalin, duloxetine, and milnacipran are used...

متن کامل

Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression in a Mouse Model of Allergic Asthma: An experimental study

Background & Aims: Allergic diseases have increased in the last decade worldwide and researchers have been trying to introduce new strategies and drugs to treat these types of diseases. Nicotine shows anti-inflammatory properties and the studies have revealed that it can reduce the inflammation and the allergic responses. The mammalian target of rapamycin (mTOR) is a multifunctional protein kin...

متن کامل

The Effect of Aerobic Exercise on Nrg1/Erbb2 Signaling Pathway In Male Rats with Diabetic Neuropathic Pain

Background: Dysfunction of Schwann cells by diabetes has far-reaching consequences for the structure and function of peripheral nerves. The aim of the present study was to evaluate the effect of aerobic exercise on the Nrg1 / ErbB2 signaling pathway in male rats with diabetic neuropathic pain. Methods: Twenty-four 8-week-old male Wistar rats (weight range 204 ± 11.3 g) were randomly divided in...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2009